Dimethylformamide → Methyl 4-phenylthiazolylcyanoacetate

HRID 1758126Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1758126
[CH2:1]([S:10][C:11]#[N:12])[C:2]([C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1)=O.CN(C=O)C.C(N(CC)CC)C.[C:25]([CH2:27][C:28]([O:30][CH3:31])=[O:29])#[N:26]>C(O)(=O)C.O>[C:4]1([C:2]2[N:12]=[C:11]([CH:27]([C:25]#[N:26])[C:28]([O:30][CH3:31])=[O:29])[S:10][CH:1]=2)[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1

Komponenten

7

Edukt 4

HCID 6228DimethylformamideHCID 7747Methyl cyanoacetateHCID 8471TriethylamineHCID 219693Phenacyl thiocyanate

Produkt 1

HCID 20510873Methyl 4-phenylthiazolylcyanoacetate

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 176Acetic AcidLösungsmittelHCID 962WaterLösungsmittel

Versuchsvorschrift

90 parts of phenacyl thiocyanate are introduced into a mixture of 150 parts of DMF, 150 parts of triethylamine and 50 parts of methyl cyanoacetate. The mixture is then stirred for 4 hours at room temperature, after which it is introduced into water and the batch is acidified with acetic acid. The product which precipitates is filtered off and dried in an oven.

Aufarbeitung

  1. customThe product which precipitates
  2. filtrationis filtered off
  3. customdried in an oven

Quellen und Nachweise

ORD-Eintrag
ord-3f94c4b018504dd88e8ccd7a2d6cdbc3
Quelldatensatz
uspto-grants-1983_02
Patentnummer
US04371734

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