5-Aminoimidazole-4-carboxamide hydrochloride → 4-(2-Thienyl)imidazo[1,5-a]pyrimidine-8-carboxamide

HRID 1758794

Reaktionsgleichung

Reaktionsgleichung von HRID 1758794
C[N:2]([CH3:12])[CH:3]=[CH:4][C:5]([C:7]1[S:8][CH:9]=[CH:10][CH:11]=1)=O.Cl.NC1[N:16]=[CH:17][NH:18][C:19]=1[C:20]([NH2:22])=[O:21].C([O-])(=O)C.[Na+]>C(O)(=O)C>[S:8]1[CH:9]=[CH:10][CH:11]=[C:7]1[C:5]1[N:16]2[CH:17]=[N:18][C:19]([C:20]([NH2:22])=[O:21])=[C:12]2[N:2]=[CH:3][CH:4]=1

Komponenten

5

Edukt 3

HCID 661465-Aminoimidazole-4-carboxamide hydrochlorideHCID 517045Sodium AcetateHCID 6023993-(Dimethylamino)-1-(2-thienyl)-2-propen-1-one

Produkt 1

HCID 205089574-(2-Thienyl)imidazo[1,5-a]pyrimidine-8-carboxamide

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 176Acetic AcidLösungsmittel

Versuchsvorschrift

A mixture of 0.01 mol of 3-dimethylamino-1-(2-thienyl)-2-propen-1-one (prepared as described in Example 1, Part A), 0.01 mol of 4amino-5-imidazolecarboxamide hydrochloride and 0.01 mol of anhydrous sodium acetate in 25 ml. of glacial acetic acid can be refluxed for 16 hours. The reaction mixture can be cooled and the crystalline precipitate collected by filtration and washed with water to produce 4-(2-thienyl)imidazo[1,5-a]pyrimidine-8-carboxamide.

Aufarbeitung

  1. customprepared
  2. temperatureThe reaction mixture can be cooled
  3. filtrationthe crystalline precipitate collected by filtration
  4. washwashed with water

Quellen und Nachweise

ORD-Eintrag
ord-aead6c4625aa4cd5aa47356fb23eea00
Quelldatensatz
uspto-grants-1983_02
Patentnummer
US04374988

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