2',3'-Didehydro-2',3'-dideoxyuridine → 2',3'-Dideoxyuridine

HRID 1762785

Reaktionsgleichung

Reaktionsgleichung von HRID 1762785
[C@@H:1]1([N:8]2[CH:15]=[CH:14][C:12](=[O:13])[NH:11][C:9]2=[O:10])[O:7][C@H:4]([CH2:5][OH:6])[CH:3]=[CH:2]1.[H][H]>CO.[Pd]>[C@@H:1]1([N:8]2[CH:15]=[CH:14][C:12](=[O:13])[NH:11][C:9]2=[O:10])[O:7][C@H:4]([CH2:5][OH:6])[CH2:3][CH2:2]1

Komponenten

5

Edukt 2

HCID 651592',3'-Didehydro-2',3'-dideoxyuridineHCID 178418361HCID 178418361, Verbindung

Produkt 1

HCID 651612',3'-Dideoxyuridine

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 887MethanolLösungsmittel

Versuchsvorschrift

A solution of 2',3'-dideoxy-2',3'-didehydrouridine (1.0 g, 4.8 mmol) in methanol (10 ml) containing a catalyst (wet 5% palladium on carbon) (400 mg) was stirred in an atmosphere of hydrogen for 1 h. The catalyst was removed by filtration and the filtrate was concentrated. The residue was chromatographed on silica gel (CHCl3 /MeOH=5/1) to give

Aufarbeitung

  1. customThe catalyst was removed by filtration
  2. concentrationthe filtrate was concentrated
  3. customThe residue was chromatographed on silica gel (CHCl3 /MeOH=5/1)
  4. customto give

Quellen und Nachweise

ORD-Eintrag
ord-05ea3faebf7541848d671bd8143d4729
Quelldatensatz
uspto-grants-1989_05
Patentnummer
US04835104

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