Hydrochloric Acid → HCID 70166468, Verbindung

HRID 1763724Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1763724
[CH3:1][O:2][C:3](=[O:30])[C@H:4]([CH2:22][C:23]1[CH:28]=[CH:27][C:26]([OH:29])=[CH:25][CH:24]=1)[NH:5][C:6](=[O:21])[C@H:7]([CH2:19][OH:20])[NH:8]C(OCC1C=CC=CC=1)=O.CO.[ClH:33].O>[Pd].O1CCCC1>[ClH:33].[CH3:1][O:2][C:3](=[O:30])[C@H:4]([CH2:22][C:23]1[CH:28]=[CH:27][C:26]([OH:29])=[CH:25][CH:24]=1)[NH:5][C:6](=[O:21])[C@H:7]([CH2:19][OH:20])[NH2:8]

Komponenten

7

Edukt 4

HCID 313Hydrochloric AcidHCID 887MethanolHCID 962WaterHCID 13190522Z-Ser-Tyr-OMe

Produkt 1

HCID 70166468HCID 70166468, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

To a mixture of 8.328 g. of Nα -benzyloxycarbonyl-L-seryl-L-tyrosine methyl ester [cf. Fischer and Whetstone, J. Am. Chem. Soc., 76, 5076 (1954)] and 500 mg. of 20% palladium on carbon is added 70 ml. of methanol containing 6.67 ml. of 3N hydrogen chloride in tetrahydrofuran and the mixture stirred under hydrogen at one inch water pressure for three hours. The mixture is filtered to remove the catalyst and the filtrate is evaporated to dryness under reduced pressure to give a residue of L-seryl-L-tyrosine methyl ester hydrochloride which is suitable for use without further purification.

Aufarbeitung

  1. additionTo a mixture of 8.328 g
  2. filtrationThe mixture is filtered
  3. customto remove the catalyst
  4. customthe filtrate is evaporated to dryness under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-b3d01121583d4361a7548b38655bd980
Quelldatensatz
uspto-grants-1978_09
Patentnummer
US04111923

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