Sodium Hydroxide → 5-(4-Methoxy-benzyl)-hydantoin

HRID 1763739

Reaktionsgleichung

Reaktionsgleichung von HRID 1763739
[CH3:1][O:2][C:3]1[CH:16]=[CH:15][C:6]([CH:7]=[C:8]2[NH:12][C:11](=[O:13])[NH:10][C:9]2=[O:14])=[CH:5][CH:4]=1.[OH-].[Na+].[H][H]>[Pd].O>[CH3:1][O:2][C:3]1[CH:4]=[CH:5][C:6]([CH2:7][CH:8]2[NH:12][C:11](=[O:13])[NH:10][C:9]2=[O:14])=[CH:15][CH:16]=1

Komponenten

6

Edukt 3

HCID 14798Sodium HydroxideHCID 947495-(p-Methoxybenzylidene)-hydantoinHCID 178418361HCID 178418361, Verbindung

Produkt 1

HCID 957275-(4-Methoxy-benzyl)-hydantoin

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 962WaterLösungsmittel

Versuchsvorschrift

5-p-Methoxybenzylidene hydantoin, 171.5 g., in 680 ml. of water, 63 g. of 50% sodium hydroxide solution and 6 g. of 20% palladium-on-carbon is shaken under a hydrogen atmosphere at a pressure of 51.5 psi. for about one and a half hours until the hydrogen pressure no longer diminishes. The reaction is vented and the mixture filtered to separate the catalyst. The filtrate is cooled and taken to pH 2 with concentrated hydrochloric acid. The solid is separated by filtration, washed with water and dried at 50° C. in a vacuum oven yielding the above named compound, mp. 177°-179° C.

Aufarbeitung

  1. filtrationthe mixture filtered
  2. customto separate the catalyst
  3. temperatureThe filtrate is cooled
  4. customThe solid is separated by filtration
  5. washwashed with water
  6. customdried at 50° C. in a vacuum oven
  7. customyielding the

Quellen und Nachweise

ORD-Eintrag
ord-5bdca0996be94c8caa70d9689cc266d8
Quelldatensatz
uspto-grants-1978_09
Patentnummer
US04111923

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