Water → 2-chloro-N-[4-(cyanomethyl)phenyl]acetamide

HRID 1768956Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1768956
[Cl:1][CH2:2][C:3](Cl)=[O:4].[NH2:6][C:7]1[CH:15]=[CH:14][C:10]([CH2:11][C:12]#[N:13])=[CH:9][CH:8]=1.O>CC(N(C)C)=O>[Cl:1][CH2:2][C:3]([NH:6][C:7]1[CH:15]=[CH:14][C:10]([CH2:11][C:12]#[N:13])=[CH:9][CH:8]=1)=[O:4]

Komponenten

5

Edukt 3

HCID 962WaterHCID 6577Chloroacetyl chlorideHCID 770004-Aminophenylacetonitrile

Produkt 1

HCID 49623062-chloro-N-[4-(cyanomethyl)phenyl]acetamideAusbeute 87,8 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 31374DimethylacetamideLösungsmittel

Versuchsvorschrift

2-Chloroacetyl chloride (3.3 ml, 5.0 g, 44 mmol) was added dropwise at 10°-15° C. to a solution of 4-aminobenzylcyanide (5.3 g, 40 mmol) in dimethyl acetamide (20 ml) and the mixture was stirred at room temperature for one hour. After pouring into water the precipitate was collected, washed with water and dried over P2O5 under reduced pressure to give the title compound (7.33 g) as nearly colorless crystals, yield: 87.8%, mp 124°-125° C.

Aufarbeitung

  1. customwas collected
  2. washwashed with water
  3. dry with materialdried over P2O5 under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-78165c549a5d413e814d61de0f271d79
Quelldatensatz
uspto-grants-1995_01
Patentnummer
US05380724

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