Water → 5-Bromo-N-(tert-butyl)pyridine-2-sulfonamide

HRID 1772661Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1772661
[Br:1][C:2]1[CH:3]=[CH:4][C:5]([S:8](Cl)(=[O:10])=[O:9])=[N:6][CH:7]=1.[C:12]([NH2:16])([CH3:15])([CH3:14])[CH3:13].O>C(Cl)Cl>[Br:1][C:2]1[CH:3]=[CH:4][C:5]([S:8]([NH:16][C:12]([CH3:15])([CH3:14])[CH3:13])(=[O:10])=[O:9])=[N:6][CH:7]=1

Komponenten

5

Edukt 3

HCID 962WaterHCID 6385Tert-ButylamineHCID 445580975-Bromopyridine-2-sulfonyl chloride

Produkt 1

HCID 711166495-Bromo-N-(tert-butyl)pyridine-2-sulfonamide

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

A solution of 5-bromopyridine-2-sulfonyl chloride (2.7 g, 10 mmol) in DCM (100 mL) was cooled to 0° C. and treated with tert-BuNH2 (5.5 mL, 52 mmol). The resulting mixture was stirred at rt for 48 h. Water (50 mL) was added and the DCM layer were separated, dried and concentrated to obtain compound 32a. 1H-NMR (400 MHz, CDCl3) δ (ppm): 8.75 (d, J=2.3 Hz, 1H), 8.03 (dd, J=8.2, 2.3 Hz, 1H), 7.90-7.94 (m, 1H), 5.02-5.07 (m, 1H), 1.23 (s, 9H).

Aufarbeitung

  1. customthe DCM layer were separated
  2. customdried
  3. concentrationconcentrated

Quellen und Nachweise

ORD-Eintrag
ord-ecd019b54a7644189cf319967949951e
Quelldatensatz
uspto-grants-2016_02
Patentnummer
US09249163B2

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