3-Aminobenzenesulfonic acid → (2S)-2-amino-3-{[(3-sulfophenyl)carbamothioyl]amino}propanoic acid

HRID 1773093Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1773093
[NH2:1][C:2]1[CH:3]=[C:4]([S:8]([OH:11])(=[O:10])=[O:9])[CH:5]=[CH:6][CH:7]=1.C(=O)([O-])O.[Na+].[C:17](Cl)(Cl)=[S:18].Cl.[NH2:22][CH2:23][C@H:24]([NH:32]C(OC(C)(C)C)=O)[C:25]([O:27]C(C)(C)C)=[O:26]>C1COCC1.O>[NH2:32][C@@H:24]([CH2:23][NH:22][C:17](=[S:18])[NH:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([S:8]([OH:11])(=[O:9])=[O:10])[CH:3]=1)[C:25]([OH:27])=[O:26]

Komponenten

7

Edukt 4

HCID 84743-Aminobenzenesulfonic acidHCID 10040ThiophosgeneHCID 516892Sodium BicarbonateHCID 86679032(S)-tert-Butyl 3-amino-2-((tert-butoxycarbonyl)amino)propanoate hydrochloride

Produkt 1

HCID 86679035(2S)-2-amino-3-{[(3-sulfophenyl)carbamothioyl]amino}propanoic acidAusbeute 5,5 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 962WaterLösungsmittelHCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

35 mg (0.2 mmol) of 3-aminobenzenesulfonic acid and 57 mg (0.68 mmol) of sodium hydrogen carbonate were added to a mixed solvent of 2.0 ml of water and 0.5 ml of THF, and stirred at room temperature for 15 minutes. 20 μl (0.26 mmol) of thiophosgene was added and stirred at room temperature for another 40 minutes. Subsequently, 60 mg (0.2 mmol) of tert-butyl (2S)-3-amino-2-{[(tert-butoxy)carbonyl]amino}propanoate hydrochloride was added and stirred overnight. Following extraction with ethyl acetate, the solvent was distilled away, and 4.0 ml of trifluoroacetic acid was added to the residue, and the resultant was stirred at room temperature for 5 hours. After distilling the solvent away, purification step A was used to obtain 3.5 mg of the title compound.

Aufarbeitung

  1. stirringstirred at room temperature for another 40 minutes
  2. stirringstirred overnight
  3. extractionextraction with ethyl acetate
  4. distillationthe solvent was distilled away
  5. addition4.0 ml of trifluoroacetic acid was added to the residue
  6. stirringthe resultant was stirred at room temperature for 5 hours
  7. distillationAfter distilling the solvent away
  8. custompurification step A

Quellen und Nachweise

ORD-Eintrag
ord-5b7b70a9e04c4ccfbdc7201446b80227
Quelldatensatz
uspto-grants-2016_02
Patentnummer
US09253997B2

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