Water → HCID 84016145, Verbindung

HRID 1778197Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1778197
C([O:3][C:4]([C:6]1[CH:7]=[N:8][N:9]([CH3:18])[C:10]=1[O:11][C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1)=[O:5])C.[Li+].[OH-].O>C1COCC1.CO>[CH3:18][N:9]1[C:10]([O:11][C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)=[C:6]([C:4]([OH:5])=[O:3])[CH:7]=[N:8]1

Komponenten

5

Edukt 3

HCID 962WaterHCID 3939Lithium HydroxideHCID 867185501-Methyl-5-phenoxy-1H-pyrazole-4-carboxylic acid ethyl ester

Produkt 1

HCID 84016145HCID 84016145, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 21899815MeOH tetrahydrofuranLösungsmittel

Versuchsvorschrift

1-Methyl-5-phenoxy-1H-pyrazole-4-carboxylic acid ethyl ester (22.6 g; 91.4 mmol) is dissolved in THF/MeOH (1/1) and LiOH in water (7.67 g; 183 mmol) is added. After 16 hours at ambient temperature the reaction mixture is washed with EtOAc. The aqueous layer is acidified with 1 N HCl and extracted with EtOAc. The organic layer is dried and evaporated.

Aufarbeitung

  1. washAfter 16 hours at ambient temperature the reaction mixture is washed with EtOAc
  2. extractionextracted with EtOAc
  3. customThe organic layer is dried
  4. customevaporated

Quellen und Nachweise

ORD-Eintrag
ord-5f092d773f20464aab47acfdc40b6913
Quelldatensatz
uspto-grants-2016_02
Patentnummer
US09266891B2

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