N-Iodosuccinimide → HCID 178493476, Verbindung

HRID 1778650Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1778650
[I:1]N1C(=O)CCC1=O.[Cl:9][C:10]1[C:15]([O:16][CH3:17])=[CH:14][C:13]([O:18][CH3:19])=[C:12]([Cl:20])[C:11]=1[C:21]1[N:26]=[C:25]2[NH:27][N:28]=[CH:29][C:24]2=[CH:23][N:22]=1>CN(C)C=O.O>[Cl:9][C:10]1[C:15]([O:16][CH3:17])=[CH:14][C:13]([O:18][CH3:19])=[C:12]([Cl:20])[C:11]=1[C:21]1[N:26]=[C:25]2[NH:27][N:28]=[C:29]([I:1])[C:24]2=[CH:23][N:22]=1

Komponenten

5

Edukt 2

HCID 120273N-IodosuccinimideHCID 867228036-(2,6-dichloro-3,5-dimethoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidine

Produkt 1

HCID 178493476HCID 178493476, VerbindungAusbeute 79,3 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 962WaterLösungsmittelHCID 6228DimethylformamideLösungsmittel

Reaktionsbedingungen

Temperatur
40 °C

Versuchsvorschrift

N-Iodosuccinimide (0.23 g, 1.0 mmol) was added to a solution of 6-(2,6-dichloro-3,5-dimethoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidine (0.30 g) in N,N-dimethylformamide (5.0 mL). The reaction mixture was stirred at 40° C. overnight. The reaction mixture was diluted with water and quenched with aqueous Na2S2O3. The precipitates formed were filtered, washed with water, ether, and dried in vacuum to afford the desired product (0.33 g). LCMS (M+H)+=450.8/452.8.

Aufarbeitung

  1. customquenched with aqueous Na2S2O3
  2. customThe precipitates formed
  3. filtrationwere filtered
  4. washwashed with water, ether
  5. customdried in vacuum

Quellen und Nachweise

ORD-Eintrag
ord-ec9633839d0b4a10960612dc61716fcc
Quelldatensatz
uspto-grants-2016_02
Patentnummer
US09266892B2

Notizen zur Reaktion

Wird geladen…