Water → [(4-Bromobutoxy)methyl]cyclopropane

HRID 1782759Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1782759
[H-].[Na+].[OH:3][CH2:4][CH:5]1[CH2:7][CH2:6]1.[Br:8][CH2:9][CH2:10][CH2:11][CH2:12]Br.O>C1(C)C=CC=CC=1>[Br:8][CH2:9][CH2:10][CH2:11][CH2:12][O:3][CH2:4][CH:5]1[CH2:7][CH2:6]1

Komponenten

6

Edukt 4

HCID 962WaterHCID 80561,4-DibromobutaneHCID 24758Sodium hydrideHCID 75644Cyclopropanemethanol

Produkt 1

HCID 43165202[(4-Bromobutoxy)methyl]cyclopropane

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 1140TolueneLösungsmittel2×

Reaktionsbedingungen

Temperatur
100 °C

Versuchsvorschrift

2.8 g of a 60% suspension of sodium hydride in mineral oil are added in portions to a solution of 5.0 g of hydroxymethylcyclopropane in 25 ml of toluene at room temperature. The mixture is then heated at 100° C. for 2 hours. After this, it is allowed to reach room temperature and a solution of 14.9 g of 1,4-dibromobutane in 15 ml of toluene is added. The mixture is left to stir at 100° C. for a further 15 hours. Then, at room temperature, 10 ml of water are added, the phases are separated, and the toluene is removed in a rotary evaporator. The product is isolated by vacuum distillation.

Aufarbeitung

  1. customto reach room temperature
  2. waitThe mixture is left
  3. customthe phases are separated
  4. customthe toluene is removed in a rotary evaporator
  5. customThe product is isolated by vacuum distillation

Quellen und Nachweise

ORD-Eintrag
ord-de5d8c77679b477e87e86417d7ec09d3
Quelldatensatz
uspto-grants-2009_03
Patentnummer
US07498460B2

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