Formic Acid → (2R)-2-({N-formyl-N-benzoxy-amino}methyl)-7-octenoic acid

To a cold solution of HCO2H (3.2 mL) and dichloromethane (10 mL) at 0° C. was added acetic anhydride (1.2 mL, 12.9 mmol). The mixture was stirred for 1 hour at 0° C. To the resulting mixture was added slowly a solution of (2R)-2-({N-benzoxy-amino}methyl)-7-octenoic acid (358 mg, 1.29 mmol) in dichloromethane (10 mL). The mixture was stirred at 0° C. for 3 hours. The volatiles were removed by evaporation under vacuum. Dichloromethane (20 mL) was added to it. It was washed with brine (20 mL×2), and dried over MgSO4. Filtration and evaporation under vacuum provided the title compound. MH+306.

1. stirringThe mixture was stirred at 0° C. for 3 hours
2. customThe volatiles were removed by evaporation under vacuum
3. additionDichloromethane (20 mL) was added to it
4. washIt was washed with brine (20 mL×2)
5. dry with materialdried over MgSO4
6. filtrationFiltration and evaporation under vacuum

ORD-Eintrag

ord-bb2911321b244392b96e0bffada4221d

Quelldatensatz

uspto-grants-2009_03

DOI

10.6084/m9.figshare.5104873.v1

Patentnummer

US07507726B2