Methanesulfonyl chloride → HCID 20189890, Verbindung

HRID 1788640Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1788640
[CH3:1][S:2](Cl)(=[O:4])=[O:3].[OH:6][CH2:7][CH:8]([CH2:12][CH2:13][CH3:14])[CH2:9][CH2:10][OH:11]>N1C=CC=CC=1.O>[CH3:1][S:2]([O:11][CH2:10][CH2:9][CH:8]([CH2:7][O:6][S:2]([CH3:1])(=[O:4])=[O:3])[CH2:12][CH2:13][CH3:14])(=[O:4])=[O:3]

Komponenten

5

Edukt 2

HCID 31297Methanesulfonyl chlorideHCID 125082552-Propylbutane-1,4-diol

Produkt 1

HCID 20189890HCID 20189890, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 962WaterLösungsmittelHCID 1049PyridineLösungsmittel

Reaktionsbedingungen

Temperatur
0 °C

Versuchsvorschrift

Methanesulphonyl chloride (16.95 g) was added dropwise to a stirred solution of 3-hydroxymethylhexan-1-ol (8.94 g) in pyridine (39.5 g), maintaining the temperature at less than 5° C. Following the addition, the reaction mixture was stirred at 0° C. for 1.5 hours, then diluted with water and extracted with dichloromethane. The extracts were washed successively with water, dilute hydrochloric acid (X 2), water, aqueous sodium bicarbonate, and water, then dried over magnesium sulphate and concentrated to give 3-methanesulphonyloxymethylhex-1-yl methanesulphonate. (16.13 g, 83%) as a yellow oil.

Aufarbeitung

  1. temperaturemaintaining the temperature at less than 5° C
  2. additionthe addition
  3. extractionextracted with dichloromethane
  4. washThe extracts were washed successively with water, dilute hydrochloric acid (X 2), water, aqueous sodium bicarbonate, and water
  5. dry with materialdried over magnesium sulphate
  6. concentrationconcentrated

Quellen und Nachweise

ORD-Eintrag
ord-b735e5a5475e4b5385211bc2dd514f1b
Quelldatensatz
uspto-grants-1987_08
Patentnummer
US04684396

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