Phenyl Isothiocyanate → N-(3-(Dimethylamino)propyl)-N'-phenylthiourea

HRID 1794052Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1794052
[C:1]1([N:7]=[C:8]=[S:9])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[CH3:10][N:11]([CH3:16])[CH2:12][CH2:13][CH2:14][NH2:15]>COC(C)(C)C.C(O)(C)C>[CH3:10][N:11]([CH3:16])[CH2:12][CH2:13][CH2:14][NH:15][C:8]([NH:7][C:1]1[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1)=[S:9]

Komponenten

5

Edukt 2

HCID 7673Phenyl IsothiocyanateHCID 7993N,N-Dimethyl-1,3-propanediamine

Produkt 1

HCID 1982459N-(3-(Dimethylamino)propyl)-N'-phenylthioureaAusbeute 70,1 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 3776IsopropanolLösungsmittelHCID 15413tert-Butyl methyl etherLösungsmittel

Versuchsvorschrift

Phenyl isothiocyanate (5.283 g, 39.1 mmole) in 30 mL t-butyl methyl ether was added to a solution of 3-(dimethylamino)propylamine (3.993 g, 39.1 mmole) in 10 mL isopropanol. After stirring 2 hr at room temp., the solid which separated was filtered out and washed with t-butyl methyl ether to afford 6.51 g of 1-[3-(dimethylamino)propyl]-3-phenylthiourea (mp 112–114° C.), part of which (2.374 g, 10 mmole) was dissolved in ethanol (20 mL) containing conc. HCl (1.67 mL, 20 mmole) and added to 2-methylnaphthoquinone dissolved in warm ethanol (35 mL). After 4 days in a stoppered flask at room temp., the mixture was concentrated, and dissolved in ethyl acetate. The solid which separated after 16 hr was filtered out, but became sticky on the filter and was discarded. The filtrate was stored another 12 days at room temp. The powder which separated was filtered out to give 600 mg of pinkish-buff powder. Of this, 325 mg was recrystallized from 10 mL methanol+60 mL ethyl acetate containing a few drops of water to give 260 mg of the title compound, mp 238–240° C.

Aufarbeitung

  1. customthe solid which separated
  2. filtrationwas filtered out
  3. washwashed with t-butyl methyl ether

Quellen und Nachweise

ORD-Eintrag
ord-b4018d9491d945a8b170c1373b33a905
Quelldatensatz
uspto-grants-2006_04
Patentnummer
US07022721B1

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