N'-(propan-2-ylidene)(tert-butoxy)carbohydrazide → N'-(propan-2-yl)(tert-butoxy)carbohydrazide

HRID 1816291Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1816291
[CH3:1][C:2](=[N:4][NH:5][C:6]([O:8][C:9]([CH3:12])([CH3:11])[CH3:10])=[O:7])[CH3:3]>[Pd].C(O)(=O)C>[CH:2]([NH:4][NH:5][C:6]([O:8][C:9]([CH3:11])([CH3:10])[CH3:12])=[O:7])([CH3:3])[CH3:1]

Komponenten

4

Edukt 1

HCID 11435207N'-(propan-2-ylidene)(tert-butoxy)carbohydrazide

Produkt 1

HCID 11217534N'-(propan-2-yl)(tert-butoxy)carbohydrazide

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 176Acetic AcidLösungsmittel

Versuchsvorschrift

1-Methylethylidene-2-tert-butoxycarbonylhydrazine, glacial acetic acid (150 mL) and 10% palladium on carbon (2.0 g) were placed in a 500 mL Parr flask. The bottle was placed on a Parr apparatus, and after evacuating and flushing the bottle with nitrogen three times, the flask was charged with hydrogen to 40 psi. After hydrogen uptake ceased, the flask was evacuated and flushed with nitrogen. Filtration through celite, eluting with ethyl acetate, and concentration afforded the crude 1-(isopropyl)-2-tert-butoxycarbonylhydrazine as an acetic acid salt.

Aufarbeitung

  1. customafter evacuating
  2. customflushing the bottle with nitrogen three times
  3. additionthe flask was charged with hydrogen to 40 psi
  4. customthe flask was evacuated
  5. customflushed with nitrogen
  6. filtrationFiltration through celite
  7. washeluting with ethyl acetate, and concentration

Quellen und Nachweise

ORD-Eintrag
ord-0849324a6ec6451f89c9d51f6e61325f
Quelldatensatz
uspto-grants-2005_04
Patentnummer
US06884801B1

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