Acetic Anhydride → Acetamide, N-(4-hydroxy-2,5-dimethylphenyl)-
Reaktionsgleichung
[NH2:1][C:2]1[C:7]([CH3:8])=[CH:6][C:5]([OH:9])=[C:4]([CH3:10])[CH:3]=1.[C:11](OC(=O)C)(=[O:13])[CH3:12]>O>[OH:9][C:5]1[C:4]([CH3:10])=[CH:3][C:2]([NH:1][C:11](=[O:13])[CH3:12])=[C:7]([CH3:8])[CH:6]=1Komponenten
4
Edukt 2
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 1
Reaktionsbedingungen
- Temperatur
- 70 °C
Versuchsvorschrift
To a suspension of 4-amino-2,5-dimethyl-phenol (6.85 g, 50 mmol) in 30 mL of water was added acetic anhydride (5.67 mL, 60 mmol). The mixture was vigorously stirred at 70° C. for 20 min and then cooled down to room temperature. The solid was collected by filtration and washed with water to give N-(4-hydroxy-2,5-dimethyl-phenyl)-acetamide as gray solid (8.1 g, 90%).
Aufarbeitung
- temperaturecooled down to room temperature
- filtrationThe solid was collected by filtration
- washwashed with water
Quellen und Nachweise
- ORD-Eintrag
- ord-319565c3bd714555a2d8cd31a5c25312
- Quelldatensatz
- uspto-grants-2006_05
- Patentnummer
- US07037909B2
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