Hydrogen Peroxide → 3-Carboxymethylsulfinyl-7-fluoro-1-methyl-4-quinolone

HRID 1823817Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1823817
[OH:1]O.[C:3]([CH2:6][S:7][C:8]1[C:17](=[O:18])[C:16]2[C:11](=[CH:12][C:13]([F:19])=[CH:14][CH:15]=2)[N:10]([CH3:20])[CH:9]=1)([OH:5])=[O:4]>C(O)(=O)C.O>[C:3]([CH2:6][S:7]([C:8]1[C:17](=[O:18])[C:16]2[C:11](=[CH:12][C:13]([F:19])=[CH:14][CH:15]=2)[N:10]([CH3:20])[CH:9]=1)=[O:1])([OH:5])=[O:4]

Komponenten

5

Edukt 2

HCID 784Hydrogen PeroxideHCID 11161467HCID 11161467, Verbindung

Produkt 1

HCID 101254203-Carboxymethylsulfinyl-7-fluoro-1-methyl-4-quinolone

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 176Acetic AcidLösungsmittelHCID 962WaterLösungsmittel

Reaktionsbedingungen

Temperatur
55 °C

Versuchsvorschrift

50% hydrogen peroxide (57 ml, 33.6 mg, 0.988 mmol) was added to a solution of 3-carboxymethylthio-7-fluoro-1-methyl-4-quinolone (4) in acetic acid (3.6 ml) at 60° C. and the mixture was stirred at 55° C. for 4 h. The hot mixture was diluted with water (12 ml) and cooled to 0° C. A white solid that precipitated was filtered off and dried under high vacuum. The yield of 3-Carboxymethylsulfinyl-7-fluoro-1-methyl-4-quinolone was 185 mg (72.7%) (5).

Aufarbeitung

  1. temperaturecooled to 0° C
  2. customA white solid that precipitated
  3. filtrationwas filtered off
  4. customdried under high vacuum

Quellen und Nachweise

ORD-Eintrag
ord-46823dcba76145fdad20c6972e0b1ae2
Quelldatensatz
uspto-grants-2006_05
Patentnummer
US07041677B2

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