Ethyl isobutyrylacetate → HCID 69052716, Verbindung

HRID 1827036Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1827036
Cl.[NH2:2][CH2:3][C:4]([C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1)=O.[C:12]([CH2:17][C:18]([O:20][CH2:21][CH3:22])=[O:19])(=O)[CH:13]([CH3:15])[CH3:14].C([O-])(=O)C.[Na+]>O>[CH2:21]([O:20][C:18]([C:17]1[C:4]([C:6]2[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=2)=[CH:3][NH:2][C:12]=1[CH:13]([CH3:15])[CH3:14])=[O:19])[CH3:22]

Komponenten

5

Edukt 3

HCID 81583Ethyl isobutyrylacetateHCID 517045Sodium AcetateHCID 2723597Ethanone, 2-amino-1-phenyl-, hydrochloride (1:1)

Produkt 1

HCID 69052716HCID 69052716, VerbindungAusbeute 93 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Reaktionsbedingungen

Temperatur
100 °C

Versuchsvorschrift

A mixture of 2-aminoacetophenone hydrochloride (1 equiv.), ethyl isobutyrylacetate (1.2 equiv.) and sodium acetate (2.4 equiv.) in H2O was stirred at 100° C. for 18 hours and then cooled to room temperature. The aqueous layer was decanted off and the oil was dissolved in ethyl acetate. It was then washed with water and brine and then dried to give (93%) of 2-isopropyl-4-phenyl-1H-pyrrole-3-carboxylic acid ethyl ester as a red brown oil.

Aufarbeitung

  1. temperaturecooled to room temperature
  2. customThe aqueous layer was decanted off
  3. dissolutionthe oil was dissolved in ethyl acetate
  4. washIt was then washed with water and brine
  5. customdried

Quellen und Nachweise

ORD-Eintrag
ord-94e4ffef0a6f4e9496b3a5260ff33ac9
Quelldatensatz
uspto-grants-2006_05
Patentnummer
US07053114B2

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