Acetic Anhydride → N-(4-methyl-5-nitropyridin-2-yl)acetamide

HRID 1828540

Reaktionsgleichung

Reaktionsgleichung von HRID 1828540
[CH3:1][C:2]1[C:7]([N+:8]([O-:10])=[O:9])=[CH:6][N:5]=[C:4]([NH2:11])[CH:3]=1.[C:12](OC(=O)C)(=[O:14])[CH3:13]>O>[CH3:1][C:2]1[C:7]([N+:8]([O-:10])=[O:9])=[CH:6][N:5]=[C:4]([NH:11][C:12](=[O:14])[CH3:13])[CH:3]=1

Komponenten

4

Edukt 2

HCID 7918Acetic AnhydrideHCID 2431652-Amino-4-methyl-5-nitropyridine

Produkt 1

HCID 13567013N-(4-methyl-5-nitropyridin-2-yl)acetamide

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Reaktionsbedingungen

Temperatur
130 °C

Versuchsvorschrift

4-Methyl-5-nitro-2-pyridinamine (3.69 g, 2.41 mmol) was added with acetic anhydride (10 ml) and stirred at 130° C. for 1.5 hours. The reaction mixture was left stand for cooling, and then added with distilled water (5.4 ml) at 0° C., heated to 130° C., and stirred for 45 minutes. The reaction mixture was left stand for cooling and concentrated, and the deposited crystals were collected by filtration and washed with distilled water to obtain the title compound (4.71 g, quantitative).

Aufarbeitung

  1. waitThe reaction mixture was left stand
  2. temperaturefor cooling
  3. temperatureheated to 130° C.
  4. stirringstirred for 45 minutes
  5. waitThe reaction mixture was left stand
  6. temperaturefor cooling
  7. concentrationconcentrated
  8. filtrationthe deposited crystals were collected by filtration
  9. washwashed with distilled water

Quellen und Nachweise

ORD-Eintrag
ord-ae1dc800dc2640f1a468cc2b45daad5f
Quelldatensatz
uspto-grants-2006_06
Patentnummer
US07056917B2

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