Acetic Anhydride → HCID 22056091, Verbindung

HRID 1830033Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1830033
[CH3:1][N:2]1[CH2:7][CH2:6][CH2:5][CH:4]([O:8][C:9]2[CH:14]=[CH:13][C:12]([NH2:15])=[CH:11][CH:10]=2)[CH2:3]1.[C:16](OC(=O)C)(=[O:18])[CH3:17]>C(Cl)Cl.CN(C1C=CN=CC=1)C>[CH3:1][N:2]1[CH2:7][CH2:6][CH2:5][CH:4]([O:8][C:9]2[CH:14]=[CH:13][C:12]([NH:15][C:16](=[O:18])[CH3:17])=[CH:11][CH:10]=2)[CH2:3]1

Komponenten

5

Edukt 2

HCID 7918Acetic AnhydrideHCID 220554854-[(1-Methyl-3-piperidinyl)oxy]benzenamine

Produkt 1

HCID 22056091HCID 22056091, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 142844-(Dimethylamino)pyridineKatalysatorHCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

4-(1-methyl-3-piperidyloxy)phenylamine (1 equivalent) was dissolved in CH2Cl2 and a catalytic amount of DMAP was added. Acetic anhydride (1.3 equivalents) was added slowly, and the solution was stirred at room temperature overnight. The reaction was then quenched with water and the aqueous layer was extracted with CH2Cl2 (3×). The combined organic extracts were dried over Na2SO4 and concentrated in vacuo, to yield N-[4-(1-methyl-3-piperidyloxy)phenyl]acetamide as a yellow oil. LC/MS (m/z) 249.3 (MH+), Rt 1.24 minutes.

Aufarbeitung

  1. customThe reaction was then quenched with water
  2. extractionthe aqueous layer was extracted with CH2Cl2 (3×)
  3. dry with materialThe combined organic extracts were dried over Na2SO4
  4. concentrationconcentrated in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-06097fb8a517401fb5fd94c6c2817dbb
Quelldatensatz
uspto-grants-2006_06
Patentnummer
US07064215B2

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