Urea → HCID 178517841, Verbindung

HRID 1831050

Reaktionsgleichung

Reaktionsgleichung von HRID 1831050
[O-]CC.[Na+].[Na].[Cl:6][C:7]1[CH:8]=[C:9]([CH:18]=[CH:19][C:20]=1[Cl:21])[O:10][C:11](=[CH:14]N(C)C)[CH:12]=O.[NH2:22][C:23]([NH2:25])=[O:24]>C(O)C.C(O)(=O)C.O>[Cl:6][C:7]1[CH:8]=[C:9]([CH:18]=[CH:19][C:20]=1[Cl:21])[O:10][C:11]1[CH:14]=[N:22][C:23]([OH:24])=[N:25][CH:12]=1

Komponenten

8

Edukt 4

HCID 1176UreaHCID 2723922Sodium ethoxideHCID 5360545SodiumHCID 545558182-(3,4-Dichlorophenoxy)-3-(dimethylamino)prop-2-enal

Produkt 1

HCID 178517841HCID 178517841, VerbindungAusbeute 17,3 %

Reagenzien, Katalysatoren, Lösungsmittel 3

HCID 176Acetic AcidLösungsmittelHCID 702EthanolLösungsmittelHCID 962WaterLösungsmittel

Reaktionsbedingungen

Temperatur
60 °C

Versuchsvorschrift

A solution of sodium ethoxide, prepared from sodium (0.95 g, 41.4 mmol), 2-(3,4-dichloro-phenoxy)-3-dimethylamino-propenal (5.38 g, 20.7 mmol) and urea (2.48 g, 41.4 mmol) in ethanol (25 ml) was heated at 60° C. for 4 hours. Water (1 ml) was added and heating was continued for an additional 2 hours. The solution was cooled to room temperature and neutralised with glacial acetic acid. Most of the solvent was removed by evaporation in vacuo. Water was added and the precipitate was isolated by suction, followed by drying in a vacuum oven, yielding the title compound (0.92 g, 17% yield) as a brown solid.

Aufarbeitung

  1. temperatureheating
  2. customMost of the solvent was removed by evaporation in vacuo
  3. additionWater was added
  4. customthe precipitate was isolated by suction
  5. customby drying in a vacuum oven

Quellen und Nachweise

ORD-Eintrag
ord-833b3decc98144cca4e5174dcc2a9b6b
Quelldatensatz
uspto-grants-2006_06
Patentnummer
US07067517B2

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