Formamide → N-(1-pyridin-4-ylethyl)formamide

HRID 1831806Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1831806
[N:1]1[CH:6]=[CH:5][C:4]([C:7](=O)[CH3:8])=[CH:3][CH:2]=1.[CH:10]([NH2:12])=[O:11].[OH-].[Na+]>C(O)=O.O>[N:1]1[CH:6]=[CH:5][C:4]([CH:7]([NH:12][CH:10]=[O:11])[CH3:8])=[CH:3][CH:2]=1

Komponenten

6

Edukt 3

HCID 713FormamideHCID 142824-AcetylpyridineHCID 14798Sodium Hydroxide

Produkt 1

HCID 2771720N-(1-pyridin-4-ylethyl)formamide

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 284Formic AcidLösungsmittel2×HCID 962WaterLösungsmittel

Versuchsvorschrift

1-Pyridin-4-yl-ethanone (24.2 g, 199.77 mmol) and 10 ml of formic acid were heated to 180° C. and formamide (126 g, 2.797 mol) in 10 ml of formic acid was added within 30 min. The mixture was stirred for 90 min., cooled and poured in 100 ml of water. After addition of conc. sodium hydroxide solution until pH13 the product was extracted with diethyl-ether. The organic layer was dried with MgSO4 and evaporated. Purification by distillation (165° C./4 mbar) yields pure product.

Aufarbeitung

  1. temperaturecooled
  2. extractionwas extracted with diethyl-ether
  3. dry with materialThe organic layer was dried with MgSO4
  4. customevaporated
  5. customPurification
  6. distillationby distillation (165° C./4 mbar)
  7. customyields pure product

Quellen und Nachweise

ORD-Eintrag
ord-51a7bbae96154048b61fe7ecbbdc2a52
Quelldatensatz
uspto-grants-2006_06
Patentnummer
US07067665B2

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