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Hydrochloric Acid → HCID 20322213, Verbindung

HRID 1833761
Notizen
Druckvorschau

Reaktionsgleichung

Reaktionsgleichung von HRID 1833761
Cl[C:2]([CH:4]([CH2:16][CH2:17][CH2:18][CH:19]([O:25][C:26](=[O:28])[CH3:27])[CH2:20][CH2:21][CH2:22][CH2:23][CH3:24])[CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][C:11]([O:13][CH2:14][CH3:15])=[O:12])=[O:3].[BH4-].[Na+].Cl.OCC(CCCC(OC(=O)C)CCCCC)CCCCCCC([O-])=O>COCCOCCOC.O>[OH:3][CH2:2][CH:4]([CH2:16][CH2:17][CH2:18][CH:19]([O:25][C:26](=[O:28])[CH3:27])[CH2:20][CH2:21][CH2:22][CH2:23][CH3:24])[CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][C:11]([O:13][CH2:14][CH3:15])=[O:12]
KomponentenVersuchsvorschriftAufarbeitungQuellen und NachweiseNotizen zur Reaktion

Komponenten

7

Edukt 4

HCID 313Hydrochloric AcidHCID 4311764Sodium borohydrideHCID 20322197Ethyl 12-(acetyloxy)-8-(chlorocarbonyl)heptadecanoateHCID 20322276HCID 20322276, Verbindung

Produkt 1

HCID 20322213HCID 20322213, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 962
Water
Lösungsmittel
HCID 8150DiglymeLösungsmittel

Versuchsvorschrift

Ethyl 8-chlorocarbonyl-12-acetoxyheptadecanoate (Example 7, Step D) (14.0 g., 0.0335 mole) is added all at once to a solution of sodium borohydride (2.7 g., 0.07 mole) in dry diglyme (75 ml.). An exothermic reaction occurs with foaming and a rise in temperature to 55°. After 2 hours, the reaction mixture is cooled in an ice bath and 10% hydrochloric acid is added dropwise until the mixture is acidic to Congo Red. Water (250 ml.) is then added; the oily product is extracted into ether, washed with after, and dried over sodium sulfate. The ether is evaporated to leave 12.2 g. of 8-hydroxymethyl-12-acetoxyheptadecanoate as a yellow oil. The product is used in the next step without further purification.

Aufarbeitung

  1. customAn exothermic reaction
  2. customto 55°
  3. temperaturethe reaction mixture is cooled in an ice bath
  4. extractionthe oily product is extracted into ether
  5. washwashed with after, and
  6. dry with materialdried over sodium sulfate
  7. customThe ether is evaporated
  8. customto leave 12.2 g
  9. customThe product is used in the next step without further purification

Quellen und Nachweise

ORD-Eintrag
ord-137cace0761f4d31a5b472685153f0e9
Quelldatensatz
uspto-grants-1978_01
DOI
10.6084/m9.figshare.5104873.v1
Patentnummer
US04066692

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