Water → 5-Fluoro-4-hydroxy-2-oxo-N-(propan-2-yl)pyrimidine-1(2H)-carboximidic acid

HRID 1834765Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1834765
[F:1][C:2]1[C:3](=[O:9])[NH:4][C:5](=[O:8])[NH:6][CH:7]=1.[CH:10]([N:13]=[C:14]=[O:15])([CH3:12])[CH3:11].O>CS(C)=O>[F:1][C:2]1[C:3](=[O:9])[NH:4][C:5](=[O:8])[N:6]([C:14](=[O:15])[NH:13][CH:10]([CH3:12])[CH3:11])[CH:7]=1

Komponenten

5

Edukt 3

HCID 962WaterHCID 33855-FluorouracilHCID 61277Isopropyl isocyanate

Produkt 1

HCID 1515285-Fluoro-4-hydroxy-2-oxo-N-(propan-2-yl)pyrimidine-1(2H)-carboximidic acidAusbeute 68,5 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 679Dimethyl SulfoxideLösungsmittel

Versuchsvorschrift

13.0g (0.1 mole) of 5-fluorouracil was dissolved in 100ml of dimethyl sulfoxide, then 9.4g (0.11mole) of isopropyl isocyanate was added thereto at room temperature and stirred at the same temperature for 15 hours. The reaction mixture was poured into 800ml of water. The resultant precipitate was filtered off, washed with water and dried to give 14.7g (68.5% yield) of 5-fluoro-1-(iso-propylcarbamoyl)-uracil melting at 275°-285° C (decomposition).

Aufarbeitung

  1. filtrationThe resultant precipitate was filtered off
  2. washwashed with water
  3. customdried

Quellen und Nachweise

ORD-Eintrag
ord-b42e7e17a7614223987f4a7a6da207d7
Quelldatensatz
uspto-grants-1978_01
Patentnummer
US04071519

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