Isopropylamine → Methyl 5-oxo-1-(propan-2-yl)pyrrolidine-3-carboxylate

HRID 1834806Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1834806
[CH:1]([NH2:4])([CH3:3])[CH3:2].[CH3:5][O:6][C:7](=[O:14])[C:8]([CH2:10][C:11](O)=[O:12])=[CH2:9]>C(OCC)C>[C:7]([CH:8]1[CH2:9][N:4]([CH:1]([CH3:3])[CH3:2])[C:11](=[O:12])[CH2:10]1)([O:6][CH3:5])=[O:14]

Komponenten

4

Edukt 2

HCID 6363IsopropylamineHCID 4613903Butanedioic acid, 2-methylene-, methyl ester

Produkt 1

HCID 20372066Methyl 5-oxo-1-(propan-2-yl)pyrrolidine-3-carboxylate

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 3283Diethyl EtherLösungsmittel

Versuchsvorschrift

In the course of 30 minutes, 59.1 g (1 mol) of isopropyl amine were added dropwise to 158 g (1 mol) of itaconic acid methyl ester in 120 ml of diethyl ether. When the slightly exothermic reaction had finished, the reaction mixture was allowed to stand for 24 hours at room temperature. Then the solvent was removed in vacuo and the residue was subjected to fractionated vacuum distillation. boiling point: 95-98° C/0.05 mm Hg; nD20 : 1.4680

Aufarbeitung

  1. customWhen the slightly exothermic reaction
  2. customThen the solvent was removed in vacuo
  3. distillationthe residue was subjected to fractionated vacuum distillation

Quellen und Nachweise

ORD-Eintrag
ord-301cc6f27425430e92edf203c395480a
Quelldatensatz
uspto-grants-1978_01
Patentnummer
US04071530

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