Acetic Acid → 8-amino-3,4-dimethyl-7-nitro-2H-isoquinolin-1-one

HRID 1835093Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1835093
C(O[C:4](=O)[C:5]([C:10]1[CH:15]=[CH:14][C:13]([N+:16]([O-:18])=[O:17])=[C:12]([NH2:19])[C:11]=1[C:20]#[N:21])(C)[C:6](=O)[CH3:7])C.C(O)(=[O:25])C.OS(O)(=O)=O>O>[NH2:19][C:12]1[C:13]([N+:16]([O-:18])=[O:17])=[CH:14][CH:15]=[C:10]2[C:11]=1[C:20](=[O:25])[NH:21][C:6]([CH3:7])=[C:5]2[CH3:4]

Komponenten

5

Edukt 3

HCID 176Acetic AcidHCID 1118Sulfuric AcidHCID 112667142-(3-Amino-2-cyano-4-nitrophenyl)-2-methyl-3-oxobutyric acid ethyl ester

Produkt 1

HCID 235029378-amino-3,4-dimethyl-7-nitro-2H-isoquinolin-1-oneAusbeute 72 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel2×

Reaktionsbedingungen

Temperatur
100 °C

Versuchsvorschrift

The ester from above (1.39 g, 4.56 mmol) was added to a mixture of acetic acid (20 mL), H2SO4 (3 mL) and water (2 mL), and the solution heated at 100° C. for 3 h. The cooled solution was diluted with water (30 mL), the precipitate was collected, washed with water and MeOH and dried to give 8-amino-3,4-dimethyl-7-nitro-2H-isoquinolin-1-one (0.76 g, 72%). mp >300° C.

Aufarbeitung

  1. customthe precipitate was collected
  2. washwashed with water and MeOH
  3. customdried

Quellen und Nachweise

ORD-Eintrag
ord-1be837e95ca14a45b6100cc25b12fdec
Quelldatensatz
uspto-grants-2004_08
Patentnummer
US06770639B2

Notizen zur Reaktion

Wird geladen…