3-Bromoquinoline → (5-Oxo-5-quinolin-3-yl-pentyl)-carbamic acid tert-butyl ester

HRID 1837918Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1837918
Br[C:2]1[CH:3]=[N:4][C:5]2[C:10]([CH:11]=1)=[CH:9][CH:8]=[CH:7][CH:6]=2.[Li]CCCC.[C:17]([O:21][C:22](=[O:34])[NH:23][CH2:24][CH2:25][CH2:26][CH2:27][C:28](=[O:33])N(OC)C)([CH3:20])([CH3:19])[CH3:18]>C(OCC)C>[C:17]([O:21][C:22](=[O:34])[NH:23][CH2:24][CH2:25][CH2:26][CH2:27][C:28](=[O:33])[C:2]1[CH:3]=[N:4][C:5]2[C:10]([CH:11]=1)=[CH:9][CH:8]=[CH:7][CH:6]=2)([CH3:20])([CH3:18])[CH3:19]

Komponenten

5

Edukt 3

HCID 214133-BromoquinolineHCID 17958956Tert-butyl (5-(methoxy(methyl)amino)-5-oxopentyl)carbamateHCID 178418339Butyllithium

Produkt 1

HCID 53998977(5-Oxo-5-quinolin-3-yl-pentyl)-carbamic acid tert-butyl ester

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 3283Diethyl EtherLösungsmittel2×

Versuchsvorschrift

To a stirred solution of 3-bromoquinoline (25 g, 120 mmol) in diethyl ether −78° C. was added nBuLi (2.5M THF, 48 ml, 120 mmol) dropwise over 30 minutes. After 30 minutes, 21-2 (3.9 g, 15 mmol), dissolved in 50 ml ether was added dropwise over 10 minutes. After 30 minutes, the cooling bath was removed. After 1.0 hour, the reaction was quenched with sat. NH4Cl. The organic portion was separated, washed with brine, dried (MgSO4) and concentrated. The residue was chromatographed (silica gel, 20-50% ethyl acetate/hexanes) to give 21-3 as a yellow solid.

Aufarbeitung

  1. additionwas added dropwise over 10 minutes
  2. waitAfter 30 minutes
  3. customthe cooling bath was removed
  4. waitAfter 1.0 hour
  5. customthe reaction was quenched with sat. NH4Cl
  6. customThe organic portion was separated
  7. washwashed with brine
  8. dry with materialdried (MgSO4)
  9. concentrationconcentrated
  10. customThe residue was chromatographed (silica gel, 20-50% ethyl acetate/hexanes)

Quellen und Nachweise

ORD-Eintrag
ord-cdd20a98e2384b6da484218c245552a1
Quelldatensatz
uspto-grants-2004_08
Patentnummer
US06784190B2

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