Acetic Acid → 4-(3-Chloro 4-fluoro-phenyl)-1,3-dihydro-indol-2-one

HRID 1839613Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1839613
[Cl:1][C:2]1[CH:3]=[C:4]([C:9]2[CH:17]=[CH:16][CH:15]=[C:14]3[C:10]=2[CH:11]=[CH:12][NH:13]3)[CH:5]=[CH:6][C:7]=1[F:8].[Br-].[Br-].[Br-].[NH+]1C=CC=CC=1.[NH+]1C=CC=CC=1.[NH+]1C=CC=CC=1.C(O)(=[O:41])C>CC(O)(C)C.C(O)C.C(O)(=O)C.[Zn]>[Cl:1][C:2]1[CH:3]=[C:4]([C:9]2[CH:17]=[CH:16][CH:15]=[C:14]3[C:10]=2[CH2:11][C:12](=[O:41])[NH:13]3)[CH:5]=[CH:6][C:7]=1[F:8]

Komponenten

6

Edukt 3

HCID 176Acetic AcidHCID 21124087PyridiniumtribromideHCID 225617164-(3-chloro-4-fluorophenyl)-1H-indole

Produkt 1

HCID 225619674-(3-Chloro 4-fluoro-phenyl)-1,3-dihydro-indol-2-oneAusbeute 64 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23994ZincKatalysatorHCID 86587657t-BuOH ethanol aceticacidLösungsmittel

Reaktionsbedingungen

Temperatur
27 °C

Versuchsvorschrift

To the suspension of 4-(3-chloro-4-fluoro-phenyl)-1H-indole (2.03 g, 8.26 mmol) in t-BuOH-ethanol-acetic acid (3:2:1) (99 mL) was added pyridinium tribromide (7.93 g, 24.79 mmol)) portionwise. The mixture was stirred at 27° C. for 3 hours, and then to the mixture was added acetic acid (40 mL). Zinc dust was added to the reaction mixture portionwise until the color changed from deep red to light yellow, and the reaction mixture was stirred at room temperature for one hour. The unreacted zinc dust was filtered off and washed with ethanol. The filtrate was concentrated, and the syrupy residue was dissolved in ethyl acetate, which was washed with water, 0.5 N HCl, sat. NaHCO3 and brine, and dried over Na2SO4. After filtration and evaporation, the crude product was triturated with diethyl ether to provide product 4-(3-chloro-4-fluoro-phenyl)-1,3-dihydro-indol-2-one (1.39 g, 64%) as a tan solid.

Aufarbeitung

  1. stirringwas stirred at room temperature for one hour
  2. filtrationThe unreacted zinc dust was filtered off
  3. washwashed with ethanol
  4. concentrationThe filtrate was concentrated
  5. dissolutionthe syrupy residue was dissolved in ethyl acetate
  6. washwhich was washed with water, 0.5 N HCl, sat. NaHCO3 and brine
  7. dry with materialdried over Na2SO4
  8. filtrationAfter filtration and evaporation
  9. customthe crude product was triturated with diethyl ether

Quellen und Nachweise

ORD-Eintrag
ord-c1c955da8ea44ce993094942f13cb52b
Quelldatensatz
uspto-grants-2004_01
Patentnummer
US06677368B2

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