1-Phenylpiperazine → 1-[(2-Methoxyquinoxalin-3-yl)aminocarbonyl]-4-phenylpiperazine

HRID 1841469

Reaktionsgleichung

Reaktionsgleichung von HRID 1841469
[CH3:1][O:2][C:3]1[C:12]([NH:13][C:14](=[O:22])OC2C=CC=CC=2)=[N:11][C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[N:4]=1.[C:23]1([N:29]2[CH2:34][CH2:33][NH:32][CH2:31][CH2:30]2)[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=1.C1CCN2C(=NCCC2)CC1>O1CCCC1>[CH3:1][O:2][C:3]1[C:12]([NH:13][C:14]([N:32]2[CH2:33][CH2:34][N:29]([C:23]3[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=3)[CH2:30][CH2:31]2)=[O:22])=[N:11][C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[N:4]=1

Komponenten

5

Edukt 3

HCID 70961-PhenylpiperazineHCID 811841,8-Diazabicyclo(5.4.0)undec-7-eneHCID 23446261Phenyl N-(2-methoxyquinoxalin-3-yl)carbamate

Produkt 1

HCID 234463101-[(2-Methoxyquinoxalin-3-yl)aminocarbonyl]-4-phenylpiperazineAusbeute 76,5 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

Phenyl N-(2-methoxyquinoxalin-3-yl)carbamate (378 mg, 1.28 mmol) and 1-phenylpiperazine (208 mg, 1.28 mmol) were dissolved in anhydrous tetrahydrofuran and thereto DBU (195 mg, 1.28 mmol) was added. The mixture was stirred at room temperature for 2 hours, concentrated under the reduced pressure to remove the solvent, and purified by column chromatography to obtain the titled compound.

Aufarbeitung

  1. concentrationconcentrated under the reduced pressure
  2. customto remove the solvent
  3. custompurified by column chromatography

Quellen und Nachweise

ORD-Eintrag
ord-e7f5406943b0490c94103ffa25628ee8
Quelldatensatz
uspto-grants-2004_01
Patentnummer
US06683184B2

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