Bromine → HCID 86657727, Verbindung

HRID 1843734Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1843734
[CH3:1][C:2]1[C:7]([C:8](=[O:10])[CH3:9])=[C:6]([CH3:11])[CH:5]=[C:4]([CH3:12])[N:3]=1.[Br:13]Br>Br.C(O)(=O)C>[BrH:13].[Br:13][CH2:9][C:8]([C:7]1[C:2]([CH3:1])=[N:3][C:4]([CH3:12])=[CH:5][C:6]=1[CH3:11])=[O:10]

Komponenten

5

Edukt 2

HCID 24408BromineHCID 2681241-(2,4,6-Trimethylpyridin-3-yl)ethan-1-one

Produkt 1

HCID 86657727HCID 86657727, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 176Acetic AcidLösungsmittel2×HCID 260Hydrogen BromideLösungsmittel

Reaktionsbedingungen

Temperatur
70 °C

Versuchsvorschrift

To a solution of 1-(2,4,6-trimethylpyridin-3-yl)ethanone (5.0 g, 30.6 mmol) in 33% HBr in acetic acid solution (10.2 mL) was added bromine (1.57 ml, 30.6 mmol) in acetic acid (10.2 mL) dropwisely. The reaction was stirred at 70° C. for 2.0 h. The solution was cooled to room temperature and washed with ether. The residue was dried under reduced pressure to give 2-bromo-1-(2,4,6-trimethylpyridin-3-yl)ethanone hydrobromide, which was used directly for the next step without further purification.

Aufarbeitung

  1. temperatureThe solution was cooled to room temperature
  2. washwashed with ether
  3. customThe residue was dried under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-672a287d3e65443c9d4ed46663c5f559
Quelldatensatz
uspto-grants-2015_02
Patentnummer
US08946268B2

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