Water → 2-Hydroxy-4-nitrobenzonitrile

HRID 18458

Reaktionsgleichung

Reaktionsgleichung von HRID 18458
Cl.N1C=CC=CC=1.C[O:9][C:10]1[CH:17]=[C:16]([N+:18]([O-:20])=[O:19])[CH:15]=[CH:14][C:11]=1[C:12]#[N:13].O>CCOC(C)=O>[OH:9][C:10]1[CH:17]=[C:16]([N+:18]([O-:20])=[O:19])[CH:15]=[CH:14][C:11]=1[C:12]#[N:13]

Komponenten

5

Edukt 3

HCID 962WaterHCID 2918672-Methoxy-4-nitrobenzonitrileHCID 10176127Pyridinium chloride

Produkt 1

HCID 2861482-Hydroxy-4-nitrobenzonitrileAusbeute 95,2 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8857Ethyl AcetateLösungsmittel

Versuchsvorschrift

Pyridine hydrochloride (100 g; 0.87 mol) and 2-methoxy-4-nitro-benzonitrile (17 g; ca 96 mmol) was heated to 200° C. for 2 hours, cooled to room temperature and carefully added H2O and EtOAc. The slurry was stirred until all solid dissolved. The organic layer was isolated, washed twice with H2O, brine then dried, filtered and evaporated to dryness to yield 15 g (95%) pure product

Aufarbeitung

  1. dissolutiondissolved
  2. customThe organic layer was isolated
  3. washwashed twice with H2O, brine
  4. customthen dried
  5. filtrationfiltered
  6. customevaporated to dryness

Quellen und Nachweise

ORD-Eintrag
ord-572a2f4a537f4d7ba786d836abdcf52a
Quelldatensatz
uspto-grants-2010_06
Patentnummer
US07741352B2

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