Diisopropylethylamine → HCID 46244510, Verbindung

HRID 1846535Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1846535
[NH:1]1[CH2:6][CH2:5][CH:4]([N:7]2[C:15]3[C:10](=[N:11][CH:12]=[CH:13][CH:14]=3)[NH:9][C:8]2=[O:16])[CH2:3][CH2:2]1.Cl[C:18]1[N:23]=[C:22]([CH3:24])[N:21]=[C:20]([O:25][C:26]2[CH:35]=[C:34]([CH3:36])[C:29]3[NH:30][C:31](=[O:33])[O:32][C:28]=3[CH:27]=2)[CH:19]=1.CCN(C(C)C)C(C)C>CN(C=O)C.O>[CH3:24][C:22]1[N:23]=[C:18]([N:1]2[CH2:2][CH2:3][CH:4]([N:7]3[C:15]4[C:10](=[N:11][CH:12]=[CH:13][CH:14]=4)[NH:9][C:8]3=[O:16])[CH2:5][CH2:6]2)[CH:19]=[C:20]([O:25][C:26]2[CH:35]=[C:34]([CH3:36])[C:29]3[NH:30][C:31](=[O:33])[O:32][C:28]=3[CH:27]=2)[N:21]=1

Komponenten

6

Edukt 3

HCID 81531DiisopropylethylamineHCID 22293182Bms-9730132×HCID 86663906HCID 86663906, Verbindung

Produkt 1

HCID 46244510HCID 46244510, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 962WaterLösungsmittelHCID 6228DimethylformamideLösungsmittel

Reaktionsbedingungen

Temperatur
80 °C

Versuchsvorschrift

38 mg (0.17 mmol) 1-piperidin-4-yl-1,3-dihydroimidazo[4,5-b]pyridin-2-one, 50 mg (0.17 mmol) 6-(6-chloro-2-methyl-pyrimidin-4-yloxy)-4-methyl-3H-benzoxazol-2-one and 0.10 mL (0.57 mmol) DIPEA were combined in 1.8 mL DMF and stirred overnight at 80° C. Then another 15 mg (0.069 mmol) 1-piperidin-4-yl-1,3-dihydroimidazo[4,5-b]pyridin-2-one were added and the mixture was further stirred overnight at RT. The reaction mixture was diluted with water, the precipitate formed was suction filtered and dried i. vac.

Aufarbeitung

  1. waitthe mixture was further stirred overnight at RT
  2. customthe precipitate formed
  3. filtrationfiltered
  4. customdried i

Quellen und Nachweise

ORD-Eintrag
ord-b42dd261e10843c9a852d933f65b7ec2
Quelldatensatz
uspto-grants-2015_02
Patentnummer
US08952014B2

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