Sodium Methoxide → 5-Chloro-7-methoxy-6-phenylpyrazolo[1,5-a]pyrimidine

HRID 1851200Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1851200
[Cl:1][C:2]1[C:7]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)=[C:6](Cl)[N:5]2[N:15]=[CH:16][CH:17]=[C:4]2[N:3]=1.[CH3:18][O-:19].[Na+]>CO.ClCCl.O>[Cl:1][C:2]1[C:7]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)=[C:6]([O:19][CH3:18])[N:5]2[N:15]=[CH:16][CH:17]=[C:4]2[N:3]=1

Komponenten

6

Edukt 2

HCID 10942334Sodium MethoxideHCID 594278075,7-Dichloro-6-phenylpyrazolo[1,5-a]pyrimidine

Produkt 1

HCID 866306725-Chloro-7-methoxy-6-phenylpyrazolo[1,5-a]pyrimidine

Reagenzien, Katalysatoren, Lösungsmittel 3

HCID 887MethanolLösungsmittelHCID 962WaterLösungsmittelHCID 6344DichloromethaneLösungsmittel2×

Versuchsvorschrift

1.00 g 5,7-dichloro-6-phenylpyrazolo[1,5-a]pyrimidine (prepared as described above) were dissolved in 20 mL methanol and 20 mL dichlormethane. 1.2 g sodium methylate was added at 0° C. and stirred at room temperature for 2 h. The solution was diluted with water and dichloromethane. The organic phase was separated and the water phase was extracted with dichloromethane. The combined organic layers were dried over Na2SO4 and the solvent was evaporated. The crude product was used without further purification.

Aufarbeitung

  1. customThe organic phase was separated
  2. extractionthe water phase was extracted with dichloromethane
  3. dry with materialThe combined organic layers were dried over Na2SO4
  4. customthe solvent was evaporated
  5. customThe crude product was used without further purification

Quellen und Nachweise

ORD-Eintrag
ord-e36001ddfe90458f8527500d22ca2b29
Quelldatensatz
uspto-grants-2015_02
Patentnummer
US08957064B2

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