Ethanol → HCID 136060800, Verbindung

HRID 1851517Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1851517
[S:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[S:6]([NH:9][C:10]1[CH:11]=[CH:12][CH:13]=[C:14]2[C:18]=1[NH:17][C:16]([C:19](=[S:21])[NH2:20])=[CH:15]2)(=[O:8])=[O:7].Br[CH2:23][C:24](=O)[C:25]([O:27][CH2:28][CH3:29])=[O:26].C(O)C.CN(C)C(=O)C>O>[S:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[S:6]([NH:9][C:10]1[CH:11]=[CH:12][CH:13]=[C:14]2[C:18]=1[NH:17][C:16]([C:19]1[S:21][CH:23]=[C:24]([C:25]([O:27][CH2:28][CH3:29])=[O:26])[N:20]=1)=[CH:15]2)(=[O:7])=[O:8]

Komponenten

6

Edukt 4

HCID 702EthanolHCID 31374DimethylacetamideHCID 66144Ethyl bromopyruvateHCID 57901763HCID 57901763, Verbindung

Produkt 1

HCID 136060800HCID 136060800, VerbindungAusbeute 36,3 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Reaktionsbedingungen

Temperatur
80 °C

Versuchsvorschrift

A mixture of 7-[(2-thienylsulfonyl)amino]-1H-indole-2-carbothioamide (0.30 g), ethyl bromopyruvate (0.21 g), ethanol (2 mL) and N,N-dimethylacetamide (2 mL) was stirred at 80° C. for 4 hr. Water was added to the reaction mixture, and the obtained crystals were filtrated, washed with water and dried. The obtained crystals were recrystallized from ethyl acetate to give the title compound (0.14 g, yield 36%) as pale-yellow crystals. melting point 240-241° C.

Aufarbeitung

  1. filtrationthe obtained crystals were filtrated
  2. washwashed with water
  3. customdried
  4. customThe obtained crystals were recrystallized from ethyl acetate

Quellen und Nachweise

ORD-Eintrag
ord-d5675cef08c6442fa90391e097f69713
Quelldatensatz
uspto-grants-2015_02
Patentnummer
US08957070B2

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