Ammonium formate → N,N-dimethylmorpholine-2-carboxamide

A mixture of 4-benzyl-N,N-dimethylmorpholine-2-carboxamide (803 mg, 3.23 mmol), ammonium formate (2.15 g, 32.3 mmol) and 10% Pd/C (400 mg) in EtOH (20 mL) was heated at 50° C. for 1 hour. After cooling to room temperature, the catalyst was filtered off, washed with EtOH. The combined filtrate and washings were concentrated, and the residue was dissolved in EtOH (20 mL). Ammonium formate (2.15 g, 32.3 mmol) and 10% Pd/C (400 mg) were added to the mixture. The mixture was heated at 50° C. for 1 hour. After cooling to room temperature, the catalyst was filtered off, washed with EtOH. The combined filtrate and washings were concentrated to afford desired product (506 mg, 98.9%) as colorless oil.

1. temperatureAfter cooling to room temperature
2. filtrationthe catalyst was filtered off
3. washwashed with EtOH
4. concentrationThe combined filtrate and washings were concentrated
5. dissolutionthe residue was dissolved in EtOH (20 mL)
6. temperatureThe mixture was heated at 50° C. for 1 hour
7. temperatureAfter cooling to room temperature
8. filtrationthe catalyst was filtered off
9. washwashed with EtOH
10. concentrationThe combined filtrate and washings were concentrated

ORD-Eintrag

ord-2b1248d825f548f289419b4b8f7641e9

Quelldatensatz

uspto-grants-2015_02

DOI

10.6084/m9.figshare.5104873.v1

Patentnummer

US08962619B2