Cyanogen Bromide → 2-Chloro-5-ethylphenylcyanamide

HRID 1858986Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1858986
[Cl:1][C:2]1[CH:8]=[CH:7][C:6]([CH2:9][CH3:10])=[CH:5][C:3]=1[NH2:4].Br[C:12]#[N:13]>O>[Cl:1][C:2]1[CH:8]=[CH:7][C:6]([CH2:9][CH3:10])=[CH:5][C:3]=1[NH:4][C:12]#[N:13]

Komponenten

4

Edukt 2

HCID 10476Cyanogen BromideHCID 124650462-Chloro-5-ethylaniline

Produkt 1

HCID 105593012-Chloro-5-ethylphenylcyanamideAusbeute 100,3 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Versuchsvorschrift

To a heterogeneous slurry of 2-chloro-5-ethylaniline (1.6 g, 10 mmol) in 60 mL of water at 4° C. was added solid BrCN (0.848 g, 8 mmol) slowly. After 5 minutes the cooling bath was removed and the heterogeneous reaction mixture was stirred at room temperature for 24 hours to yield the product in water suspension. The precipitates were collected by filtration, washed with water (100 mL), and dried under vacuum to yield the pure title compound (1.45 g, 80% yield).

Aufarbeitung

  1. customAfter 5 minutes the cooling bath was removed
  2. customto yield the product in water suspension
  3. filtrationThe precipitates were collected by filtration
  4. washwashed with water (100 mL)
  5. customdried under vacuum

Quellen und Nachweise

ORD-Eintrag
ord-63774565f3e0431f925976ea2cb9b52a
Quelldatensatz
uspto-grants-2000_11
Patentnummer
US06153604

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