Acetic Anhydride → N-(1,4,5,6-Tetrahydro-5-methyl-4,6-dioxo-2-pyrimidinyl)acetamide

HRID 1862829Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1862829
[NH2:1][C:2]1[NH:3][C:4](=[O:10])[CH:5]([CH3:9])[C:6](=[O:8])[N:7]=1.[C:11](OC(=O)C)(=[O:13])[CH3:12]>C(O)(=O)C>[C:11]([NH:1][C:2]1[NH:7][C:6](=[O:8])[CH:5]([CH3:9])[C:4](=[O:10])[N:3]=1)(=[O:13])[CH3:12]

Komponenten

4

Edukt 2

HCID 7918Acetic AnhydrideHCID 27247262-amino-5-methyl-1H-pyrimidine-4,6-dione

Produkt 1

HCID 20393810N-(1,4,5,6-Tetrahydro-5-methyl-4,6-dioxo-2-pyrimidinyl)acetamide

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 176Acetic AcidLösungsmittel

Versuchsvorschrift

80 parts of 2-amino-4,6-dioxo-5-methyl-pyrimidine are treated for 8 hours under reflux in a mixture comprising 500 parts by volume of acetic acid and 108 parts by volume of acetic anhydride. 87 parts of the desired product are obtained by filtration, washing with ether and drying in vacuo.

Quellen und Nachweise

ORD-Eintrag
ord-d6c4d46621f341e6a7072144e29143c3
Quelldatensatz
uspto-grants-1979_09
Patentnummer
US04166852

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