1,1-Dichloroethane → 1-(3-Chloropyridin-2-yl)piperazine

HRID 1868010

Reaktionsgleichung

Reaktionsgleichung von HRID 1868010
[Cl:1][C:2]1[C:3]([N:8]2[CH2:13][CH2:12][N:11](C(OC(C)(C)C)=O)[CH2:10][CH2:9]2)=[N:4][CH:5]=[CH:6][CH:7]=1.C(O)(C(F)(F)F)=O.ClC(Cl)C>ClCCl>[Cl:1][C:2]1[C:3]([N:8]2[CH2:9][CH2:10][NH:11][CH2:12][CH2:13]2)=[N:4][CH:5]=[CH:6][CH:7]=1

Komponenten

5

Edukt 3

HCID 63651,1-DichloroethaneHCID 6422Trifluoroacetic acid2×HCID 11630777Tert-butyl 4-(3-chloropyridin-2-yl)piperazine-1-carboxylate

Produkt 1

HCID 114129441-(3-Chloropyridin-2-yl)piperazine

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

To a clear solution of tert-butyl 4-(3-chloropyridin-2-yl)piperazine-1-carboxylate in anhydrous dichloromethane (25 mL) was added TFA (25 mL) dropwise. The yellow solution was stirred at room temperature for 2.5 hour. Reaction was complete as determined by TLC. TFA was azeotropped with dichloroethane to give 1-(3-chloropyridin-2-yl)piperazine in quantitative yield (1.265 g).

Aufarbeitung

  1. customReaction

Quellen und Nachweise

ORD-Eintrag
ord-30b29d4f567642f38fcd9d67ddf87c72
Quelldatensatz
uspto-grants-2009_12
Patentnummer
US07632838B2

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