Morpholine → 5-Chloro-1H-indole-2-carboxylic acid (2-morpholin-4-yl-2-oxo-ethyl)-amide
Reaktionsgleichung
[NH:1]1[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1.[Cl:7][C:8]1[CH:9]=[C:10]2[C:14](=[CH:15][CH:16]=1)[NH:13][C:12]([C:17]([NH:19][CH2:20][C:21](O)=[O:22])=[O:18])=[CH:11]2>CCOCC>[N:1]1([C:21](=[O:22])[CH2:20][NH:19][C:17]([C:12]2[NH:13][C:14]3[C:10]([CH:11]=2)=[CH:9][C:8]([Cl:7])=[CH:16][CH:15]=3)=[O:18])[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1Komponenten
4
Edukt 2
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 1
Versuchsvorschrift
Morpholine (1.0 mmol) and [(5-chloro-1H-indole-2-carbonyl)-amino]-acetic acid (1.0 mmol) were coupled according to Procedure A. The resulting solid was suspended in ether, filtered and dried to give a beige solid: Yield, 264 mg, 71%; HPLC (60/40) 3.28 minutes (100%); TSPMS 322/324 (MH+, 100%);