Water → Methyl 4-hydrazinocarbonothioylamino-2-nitrobenzoate

HRID 1881552

Reaktionsgleichung

[CH3:1][O:2][C:3]([C:5]1[CH:10]=[CH:9][C:8]([N:11]=[C:12]=[S:13])=[CH:7][C:6]=1[N+:14]([O-:16])=[O:15])=[O:4].O.[NH2:18][NH2:19].O>O1CCCC1>[NH:18]([C:12]([NH:11][C:8]1[CH:9]=[CH:10][C:5]([C:3]([O:2][CH3:1])=[O:4])=[C:6]([N+:14]([O-:16])=[O:15])[CH:7]=1)=[S:13])[NH2:19]

Komponenten

Reaktionsbedingungen

Temperatur: 0 °C

Versuchsvorschrift

A solution of the above synthesized 4-methoxycarbonyl-3-nitrophenyl isothiocyanate (149 mg, 0.62 mmol) in tetrahydrofuran (2.2 ml) was added dropwise to a solution of hydrazine monohydrate (94 mg, 1.87 mmol) in tetrahydrofuran (4.0 ml) at 0° C. over 20 minutes. After stirring at 0° C. for further 40 minutes, water was added, and the precipitated solid was filtered to obtain 142 mg of the desired product as a colorless solid (yield 85%).

Aufarbeitung

filtrationthe precipitated solid was filtered

Quellen und Nachweise

ORD-Eintrag: ord-bd51343a360a44a7bdf07dfa33514e1f
Quelldatensatz: uspto-grants-2012_11
DOI: 10.6084/m9.figshare.5104873.v1
Patentnummer: US08318796B2

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