Ammonium formate → 3-(N-BOC-N-(2-fluoroethyl)amino)pyrrolidine

HRID 1885

Reaktionsgleichung

Reaktionsgleichung von HRID 1885
C([N:8]1[CH2:12][CH2:11][CH:10]([N:13]([C:17]([O:19][C:20]([CH3:23])([CH3:22])[CH3:21])=[O:18])[CH2:14][CH2:15][F:16])[CH2:9]1)C1C=CC=CC=1.C([O-])=O.[NH4+]>[Pd]>[C:17]([N:13]([CH:10]1[CH2:11][CH2:12][NH:8][CH2:9]1)[CH2:14][CH2:15][F:16])([O:19][C:20]([CH3:22])([CH3:23])[CH3:21])=[O:18]

Komponenten

4

Edukt 2

HCID 2723923Ammonium formateHCID 196914211-benzyl-3-(N-BOC-N-(2-fluoroethyl)amino)pyrrolidine

Produkt 1

HCID 196914543-(N-BOC-N-(2-fluoroethyl)amino)pyrrolidine

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 23938PalladiumKatalysator

Versuchsvorschrift

A 225 mg sample of the compound from step 448a was treated with ammonium formate and 10% Pd/C according to the procedure of step 445b for 1 hour, and the title compound was isolated (190 mg).

Quellen und Nachweise

ORD-Eintrag
ord-e4fd5c455c0c484e90968bd95fad35ab
Quelldatensatz
uspto-grants-1998_03
Patentnummer
US05726182

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