2-Chlorobenzoic Acid → HCID 67333501, Verbindung

HRID 1886941Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1886941
[NH2:1][C:2]1[CH:7]=[C:6]([N+:8]([O-:10])=[O:9])[CH:5]=[CH:4][C:3]=1[SH:11].[Cl:12][C:13]1[CH:21]=[CH:20][CH:19]=[CH:18][C:14]=1[C:15](O)=O.CS(O)(=O)=O.O=P12OP3(OP(OP(O3)(O1)=O)(=O)O2)=O.[OH-].[Na+]>O>[Cl:12][C:13]1[CH:21]=[CH:20][CH:19]=[CH:18][C:14]=1[C:15]1[S:11][C:3]2[CH:4]=[CH:5][C:6]([N+:8]([O-:10])=[O:9])=[CH:7][C:2]=2[N:1]=1

Komponenten

6

Edukt 4

HCID 83742-Chlorobenzoic AcidHCID 14798Sodium HydroxideHCID 63364002-Amino-4-nitrobenzenethiolHCID 86584057Phosphorus Pentoxide-Methanesulfonic Acid

Produkt 1

HCID 67333501HCID 67333501, VerbindungAusbeute 98,5 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Reaktionsbedingungen

Temperatur
130 °C

Versuchsvorschrift

2-Amino-4-nitrobenzenethiol (315 mg, 1.85 mmol), 2-chlorobenzoic acid (290 mg, 1.85 mmol) and Eaton's reagent (5 mL) were combined and heated in the microwave at 130° C. for 10 min. After cooling, the mixture was poured into water and basified with 5M aqueous sodium hydroxide to give a precipitate, which was filtered off and dried to afford 530 mg (98%) of the title compound.

Aufarbeitung

  1. temperatureAfter cooling
  2. customto give a precipitate, which
  3. filtrationwas filtered off
  4. customdried

Quellen und Nachweise

ORD-Eintrag
ord-1ae6adcfe5d643beab92b093868433dc
Quelldatensatz
uspto-grants-2013_08
Patentnummer
US08501713B2

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