Ethanol → HCID 178456333, Verbindung

A mixture of 4-(6-(4-isopropylpiperazin-1-yl)pyridin-3-yl)benzonitrile (330 mg, 1.1 mmol, prepared as described in Example 10), ethanol (15 mL), hydroxylamine hydrochloride (225 mg, 3.2 mmol), potassium carbonate (240 mg, 1.7 mmol) and water (1.5 mL) was stirred at reflux temperature overnight. The reaction mixture was allowed to cool to rt, and the solid was isolated by filtration and dried. The solid was then stirred with water (10 mL) to remove inorganic residues. The mixture was filtered and the solid was washed with water and a small portion of ethanol. Drying in vacuo afforded 260 mg (71%) of N-hydroxy-4-(6-(4-isopropylpiperazin-1-yl)pyridine-3-yl)benzamidine.

1. temperatureat reflux temperature overnight
2. customthe solid was isolated by filtration
3. customdried
4. stirringThe solid was then stirred with water (10 mL)
5. customto remove inorganic residues
6. filtrationThe mixture was filtered
7. washthe solid was washed with water
8. customDrying in vacuo

ORD-Eintrag

ord-1e9b0e38197742e7b57e01a293a3f224

Quelldatensatz

uspto-grants-2013_08

DOI

10.6084/m9.figshare.5104873.v1

Patentnummer

US08501739B2