Triethylamine → HCID 178477699, Verbindung

HRID 1888277

Reaktionsgleichung

Reaktionsgleichung von HRID 1888277
Cl.[NH:2]1[CH2:7][CH2:6][CH:5]([C:8]2[C:16]3[C:11](=[C:12]([C:23]([NH2:25])=[O:24])[CH:13]=[C:14]([C:17]4[CH:18]=[N:19][CH:20]=[CH:21][CH:22]=4)[CH:15]=3)[NH:10][N:9]=2)[CH2:4][CH2:3]1.[CH2:26]([S:28](Cl)(=[O:30])=[O:29])[CH3:27].C(N(CC)CC)C>C(Cl)Cl>[CH2:26]([S:28]([N:2]1[CH2:7][CH2:6][CH:5]([C:8]2[C:16]3[C:11](=[C:12]([C:23]([NH2:25])=[O:24])[CH:13]=[C:14]([C:17]4[CH:18]=[N:19][CH:20]=[CH:21][CH:22]=4)[CH:15]=3)[NH:10][N:9]=2)[CH2:4][CH2:3]1)(=[O:30])=[O:29])[CH3:27]

Komponenten

5

Edukt 3

HCID 8471TriethylamineHCID 11667Ethanesulfonyl chlorideHCID 178479540HCID 178479540, Verbindung2×

Produkt 1

HCID 178477699HCID 178477699, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

This compound was prepared in a fashion analogous to the procedure described in Example 3. Thus 3-(4-piperidinyl)-5-(3-pyridinyl)-1H-indazole-7-carboxamide hydrochloride (Intermediate 21) (0.09 mmol) was reacted with ethane sulfonyl chloride (0.01 mL, 0.217 mmol) in the presence of triethylamine (0.04 mL, 0.468 mmol) in methylene chloride (10 mL) to give the title compound (4.9 mg, 13% for the last two steps)

Aufarbeitung

  1. customThis compound was prepared in a fashion analogous to the procedure

Quellen und Nachweise

ORD-Eintrag
ord-06aebaefeaeb4ed088fcd0e4819e3401
Quelldatensatz
uspto-grants-2013_08
Patentnummer
US08501780B2

Verknüpfte Notizen

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