Acetic Anhydride → 4-Acetyl-6-methoxy-1H-2-benzopyran-1,3(4H)-dione

HRID 1895868Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1895868
N[C@H:2]([C:5](O)=[O:6])C[SeH].[C:8]([CH2:11][C:12]1[CH:20]=[C:19]([O:21][CH3:22])[CH:18]=[CH:17][C:13]=1[C:14]([OH:16])=[O:15])([OH:10])=O.C(OC(=O)C)(=O)C>N1C=CC=CC=1.C(OCC)C>[C:5]([CH:11]1[C:12]2[C:13](=[CH:17][CH:18]=[C:19]([O:21][CH3:22])[CH:20]=2)[C:14](=[O:15])[O:16][C:8]1=[O:10])(=[O:6])[CH3:2]

Komponenten

6

Edukt 3

HCID 7918Acetic AnhydrideHCID 25076L-SelenocysteineHCID 118166262-(Carboxymethyl)-4-methoxybenzoic acid

Produkt 1

HCID 578931304-Acetyl-6-methoxy-1H-2-benzopyran-1,3(4H)-dione

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 1049PyridineLösungsmittelHCID 3283Diethyl EtherLösungsmittel

Versuchsvorschrift

Following a literature procedure (Ind. J. Chem. Sec. B, 1986, 25B, 640-643), 2-carboxymethyl-4-methoxybenzoic acid (41; 1.0 g; 4.8 mmol) was dissolved in a mixture of pyridine (1.4 mL) and acetic anhydride (8.6 mL; 9.3 g; 91 mmol) then stirred for 3 h during which time a solid had formed. The suspension was diluted with diethyl ether, filtered and the filter cake washed with diethyl ether. Yield: 905 mg (81%) of the title compound.

Aufarbeitung

  1. customhad formed
  2. filtrationfiltered
  3. washthe filter cake washed with diethyl ether

Quellen und Nachweise

ORD-Eintrag
ord-9dbcd17b4c6246988894397593cd8cad
Quelldatensatz
uspto-grants-2013_08
Patentnummer
US08518874B2

Notizen zur Reaktion

Wird geladen…