Water → 6-chloro-3-(6-chloropyrazin-2-yl)-3H-imidazo[4,5-c]pyridine 6-chloro-1-(6-chloropyrazin-2-yl)-1H-imidazo[4,5-c]pyridine

HRID 1896207

Reaktionsgleichung

Reaktionsgleichung von HRID 1896207
[Cl:1][C:2]1[N:7]=[CH:6][C:5]2[NH:8][CH:9]=[N:10][C:4]=2[CH:3]=1.[Cl:11][C:12]1[CH:17]=[N:16][CH:15]=[C:14]([Cl:18])[N:13]=1.[F-].[Cs+].O>CS(C)=O>[Cl:1][C:2]1[N:7]=[CH:6][C:5]2[N:8]([C:14]3[CH:15]=[N:16][CH:17]=[C:12]([Cl:11])[N:13]=3)[CH:9]=[N:10][C:4]=2[CH:3]=1.[Cl:1][C:2]1[N:7]=[CH:6][C:5]2[N:8]=[CH:9][N:10]([C:12]3[CH:17]=[N:16][CH:15]=[C:14]([Cl:18])[N:13]=3)[C:4]=2[CH:3]=1

Komponenten

6

Edukt 4

HCID 962WaterHCID 25953Cesium fluorideHCID 785042,6-DichloropyrazineHCID 218138956-Chloro-3H-imidazo(4,5-c)pyridine

Produkt 1

HCID 866543176-chloro-3-(6-chloropyrazin-2-yl)-3H-imidazo[4,5-c]pyridine 6-chloro-1-(6-chloropyrazin-2-yl)-1H-imidazo[4,5-c]pyridine

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 679Dimethyl SulfoxideLösungsmittel

Versuchsvorschrift

A mixture of 6-chloro-3H-imidazo[4,5-c]pyridine (4.6 g, 30 mmol), 2,6-dichloropyrazine (6 g, 40.5 mmol) and CsF (9.1 g, 60 mmol) in dry DMSO (80 mL) was stirred at room temperature for 20 h under N2. The mixture was poured into water (50 mL) with stirring. The formed precipitate was collected by filtration. The filter cake was suspended in MeOH (20 mL) and filtered again. The filter cake was collected and dried in vacuum which gave a mixture of title compounds 18a & 17a as a white solid (5.0 g, 62.9%).

Aufarbeitung

  1. stirringwith stirring
  2. filtrationThe formed precipitate was collected by filtration
  3. filtrationfiltered again
  4. customThe filter cake was collected
  5. customdried in vacuum which
  6. customgave

Quellen und Nachweise

ORD-Eintrag
ord-46677eac6d294294a28584219bfc6d41
Quelldatensatz
uspto-grants-2013_08
Patentnummer
US08518952B2

Verknüpfte Notizen

Wird geladen…