Water → HCID 22924391, Verbindung

HRID 1901502

Reaktionsgleichung

Reaktionsgleichung von HRID 1901502
[CH:1]1([N:4]2[C:13]3[C:8](=[C:9]([CH:17]=[CH2:18])[C:10]([F:16])=[C:11](F)[C:12]=3[F:14])[C:7](=[O:19])[C:6]([C:20]([OH:22])=[O:21])=[CH:5]2)[CH2:3][CH2:2]1.[CH3:23][N:24]1[CH2:29][CH:28]2[CH2:30][CH:25]1[CH2:26][NH:27]2.C1N2CCN(CC2)C1.O>C(#N)C.CN(C)C=O>[CH:1]1([N:4]2[C:13]3[C:8](=[C:9]([CH:17]=[CH2:18])[C:10]([F:16])=[C:11]([N:27]4[CH2:26][CH:25]5[CH2:30][CH:28]4[CH2:29][N:24]5[CH3:23])[C:12]=3[F:14])[C:7](=[O:19])[C:6]([C:20]([OH:22])=[O:21])=[CH:5]2)[CH2:2][CH2:3]1

Komponenten

7

Edukt 4

HCID 962WaterHCID 9237DabcoHCID 102194032-Methyl-2,5-diazabicyclo[2.2.1]heptaneHCID 152976601-Cyclopropyl-6,7,8-trifluoro-1,4-dihydro-4-oxo-5-vinyl-3-quinolinecarboxylic acid

Produkt 1

HCID 22924391HCID 22924391, VerbindungAusbeute 74,6 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 6228DimethylformamideLösungsmittelHCID 6342AcetonitrileLösungsmittel

Versuchsvorschrift

0.93 g of 1-cyclopropyl-6,7,8-trifluoro-1,4-dihydro-4-oxo-5-vinyl-3-quinolinecarboxylic acid, 0.5 g of 2-methyl-2,5-diazabicyclo[2.2.1]heptane and 0.36 g of DABCO are refluxed for 2 hours in a mixture of 6 ml of acetonitrile and 3 ml of dimethylformamide. At room temperature, the reaction mixture is treated with 2 ml of water, and the solid is filtered off with suction, washed with water and dried. 0.9 g of 1-cyclopropyl-6,8-difluoro-1,4-dihydro-7-(2-methyl-2,5-diazabicyclo[2.2.1]-hept-5-yl)-4-oxo-5-vinyl-3-quinolinecarboxylic acid is obtained.

Aufarbeitung

  1. filtrationthe solid is filtered off with suction
  2. washwashed with water
  3. customdried

Quellen und Nachweise

ORD-Eintrag
ord-786e33501018494ca55cea1629324c8a
Quelldatensatz
uspto-grants-1996_11
Patentnummer
US05578604

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