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Hydrogen Bromide → 5-(4-Chloro-2-methylphenylcarbamoyl)-4-{4-cyclopropyl-5-[3-(2,2-dimethylpropyl)cyclobutyl]isoxazol-3-yl}valeric acid

HRID 1912082
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Druckvorschau

Reaktionsgleichung

Reaktionsgleichung von HRID 1912082
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([NH:8][C:9]([CH2:11][CH:12]([C:19]2[C:23]([CH:24]3[CH2:26][CH2:25]3)=[C:22]([CH:27]3[CH2:30][CH:29]([CH2:31][C:32]([CH3:35])([CH3:34])[CH3:33])[CH2:28]3)[O:21][N:20]=2)[CH2:13][CH2:14][C:15]([O:17]C)=[O:16])=[O:10])=[C:4]([CH3:36])[CH:3]=1.Br.C([O-])(=O)C.[Na+]>C(O)(=O)C>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([NH:8][C:9]([CH2:11][CH:12]([C:19]2[C:23]([CH:24]3[CH2:25][CH2:26]3)=[C:22]([CH:27]3[CH2:28][CH:29]([CH2:31][C:32]([CH3:34])([CH3:33])[CH3:35])[CH2:30]3)[O:21][N:20]=2)[CH2:13][CH2:14][C:15]([OH:17])=[O:16])=[O:10])=[C:4]([CH3:36])[CH:3]=1
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Komponenten

5

Edukt 3

HCID 260Hydrogen BromideHCID 517045Sodium AcetateHCID 71114755Methyl 5-(4-chloro-2-methylphenylcarbamoyl)-4-{4-cyclopropyl-5-[3-(2,2-dimethylpropyl)cyclobutyl]isoxazol-3-yl}valerate

Produkt 1

HCID 711147445-(4-Chloro-2-methylphenylcarbamoyl)-4-{4-cyclopropyl-5-[3-(2,2-dimethylpropyl)cyclobutyl]isoxazol-3-yl}valeric acidAusbeute 69,6 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 176Acetic AcidLösungsmittel

Reaktionsbedingungen

Temperatur
60 °C

Versuchsvorschrift

Methyl 5-(4-chloro-2-methylphenylcarbamoyl)-4-{4-cyclopropyl-5-[3-(2,2-dimethylpropyl)cyclobutyl]isoxazol-3-yl}valerate (72.5 mg) and acetic acid (0.725 mL) were mixed. To the mixture was added 48 w/v % hydrobromic acid (0.363 mL) at RT. The mixture was stirred at 60° C., and then to the reaction mixture was added sodium acetate (287 mg) at ice temperature. The mixture was extracted with ethyl acetate. The organic layer was washed with water and brine, then dried over magnesium sulfate. The magnesium sulfate was filtered off and the filtrate was concentrated in vacuo. The resultant residue was purified by preparative chromatography (Eluent: methanol/chloroform/acetic acid=1/20/0.05) to give the title compound (49.1 mg). The specific optical rotation value of the title compound was [α]D25=+32.0° (c=1.00, methanol). The title compound was analyzed using a chiral column. The retention time of the title compound was 26.8 min., and the optical purity thereof was 94.8% ee.

Aufarbeitung

  1. extractionThe mixture was extracted with ethyl acetate
  2. washThe organic layer was washed with water and brine
  3. dry with materialdried over magnesium sulfate
  4. filtrationThe magnesium sulfate was filtered off
  5. concentrationthe filtrate was concentrated in vacuo
  6. customThe resultant residue was purified by preparative chromatography (Eluent: methanol/chloroform/acetic acid=1/20/0.05)

Quellen und Nachweise

ORD-Eintrag
ord-87a47da439664b3ab572411747fd9dbf
Quelldatensatz
uspto-grants-2013_12
DOI
10.6084/m9.figshare.5104873.v1
Patentnummer
US08604069B2

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