Morpholine → 5-Chloro-2-methyl-7-morpholin-4-yl-thiazolo[4,5-d]pyrimidine

HRID 1919359Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1919359
[Cl:1][C:2]1[N:3]=[C:4](Cl)[C:5]2[S:10][C:9]([CH3:11])=[N:8][C:6]=2[N:7]=1.[NH:13]1[CH2:18][CH2:17][O:16][CH2:15][CH2:14]1>CO.CCOC(C)=O.O>[Cl:1][C:2]1[N:3]=[C:4]([N:13]2[CH2:18][CH2:17][O:16][CH2:15][CH2:14]2)[C:5]2[S:10][C:9]([CH3:11])=[N:8][C:6]=2[N:7]=1

Komponenten

6

Edukt 2

HCID 8083MorpholineHCID 582349525,7-Dichloro-2-methylthiazolo[4,5-d]pyrimidine

Produkt 1

HCID 582349545-Chloro-2-methyl-7-morpholin-4-yl-thiazolo[4,5-d]pyrimidineAusbeute 90 %

Reagenzien, Katalysatoren, Lösungsmittel 3

HCID 887MethanolLösungsmittelHCID 962WaterLösungsmittelHCID 8857Ethyl AcetateLösungsmittel

Versuchsvorschrift

To a solution of 5,7-dichloro-2-methyl-thiazolo[4,5-d]pyrimidine (92 mg, 0.42 mmol) in MeOH (3 mL) was added morpholine (81 μL, 0.93 mmol) and the mixture stirred at RT for 1 h. The reaction mixture was diluted with EtOAc and H2O. The organic layer was isolated, washed with brine, then dried (MgSO4) and concentrated in vacuo. The resultant residue was purified by column chromatography to give the title compound as a cream solid (102 mg, 90%).

Aufarbeitung

  1. customThe organic layer was isolated
  2. washwashed with brine
  3. dry with materialdried (MgSO4)
  4. concentrationconcentrated in vacuo
  5. customThe resultant residue was purified by column chromatography

Quellen und Nachweise

ORD-Eintrag
ord-eaea9edf5a8c483c9cb144b3e1addc39
Quelldatensatz
uspto-grants-2012_05
Patentnummer
US08168633B2

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