Lithium Hydroxide → {3-[2-(Dimethylamino)-2-oxoethyl]-5,7-dimethyl-2-oxo-2,3-dihydro-1H-benzimidazol-1-yl}acetic acid

HRID 1921181Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1921181
[OH-].[Li+].[CH3:3][N:4]([CH3:25])[C:5](=[O:24])[CH2:6][N:7]1[C:11]2[CH:12]=[C:13]([CH3:17])[CH:14]=[C:15]([CH3:16])[C:10]=2[N:9]([CH2:18][C:19]([O:21]C)=[O:20])[C:8]1=[O:23]>C1COCC1.O>[CH3:25][N:4]([CH3:3])[C:5](=[O:24])[CH2:6][N:7]1[C:11]2[CH:12]=[C:13]([CH3:17])[CH:14]=[C:15]([CH3:16])[C:10]=2[N:9]([CH2:18][C:19]([OH:21])=[O:20])[C:8]1=[O:23]

Komponenten

5

Edukt 2

HCID 3939Lithium HydroxideHCID 86619733Methyl {3-[2-(dimethylamino)-2-oxoethyl]-5,7-dimethyl-2-oxo-2,3-dihydro-1H-benzimidazol-1-yl}acetate

Produkt 1

HCID 59279577{3-[2-(Dimethylamino)-2-oxoethyl]-5,7-dimethyl-2-oxo-2,3-dihydro-1H-benzimidazol-1-yl}acetic acid

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 962WaterLösungsmittel2×HCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

Lithium hydroxide (131 mg, 3.12 mmol) was added to a solution of methyl {3-[2-(dimethylamino)-2-oxoethyl]-5,7-dimethyl-2-oxo-2,3-dihydro-1H-benzimidazol-1-yl}acetate from Step A (333 mg, 1.04 mmol) in THF (3 mL) and H2O (1 mL). After 72 h, H2O was added and the precipitate was collected by filtration to give the title compound. MS: m/z=306 (M+1).

Aufarbeitung

  1. filtrationthe precipitate was collected by filtration

Quellen und Nachweise

ORD-Eintrag
ord-fe0b92d65e81416b949e2f31c01267eb
Quelldatensatz
uspto-grants-2012_05
Patentnummer
US08173655B2

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